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Role of G protein-coupled receptors (GPCR), matrix metalloproteinases 2 and 9 (MMP2 and MMP9), heparin-binding epidermal growth factor-like growth factor (hbEGF), epidermal growth factor receptor (EGFR), erbB2, and insulin-like growth factor 1 receptor (IGF-1R) in trenbolone acetate-stimulated bovine satellite cell proliferation.
Thornton KJ, Kamange-Sollo E, White ME, Dayton WR. Thornton KJ, et al. J Anim Sci. 2015 Sep;93(9):4291-301. doi: 10.2527/jas.2015-9191. J Anim Sci. 2015. PMID: 26440329
The classical genomic actions of testosterone have been well characterized; however, our results indicate that TBA may also initiate a quicker, nongenomic response that involves activation of G protein-coupled receptors (GPCR) resulting in activation of matrix metalloproteinases …
The classical genomic actions of testosterone have been well characterized; however, our results indicate that TBA may also initiate a quick …
Active G protein-coupled receptors (GPCR), matrix metalloproteinases 2/9 (MMP2/9), heparin-binding epidermal growth factor (hbEGF), epidermal growth factor receptor (EGFR), erbB2, and insulin-like growth factor 1 receptor (IGF-1R) are necessary for trenbolone acetate-induced alterations in protein turnover rate of fused bovine satellite cell cultures.
Thornton KJ, Kamanga-Sollo E, White ME, Dayton WR. Thornton KJ, et al. J Anim Sci. 2016 Jun;94(6):2332-43. doi: 10.2527/jas.2015-0178. J Anim Sci. 2016. PMID: 27285910
We hypothesized that TBA activates GPCR, resulting in activation of MMP2/9 that releases hbEGF, which activates the EGFR and/or erbB2. ...Alternatively, inhibition of GPCR, MMP2/9, hbEGF, EGFR, erbB2, or IGF-1R in the presence of 10 n TBA each had no ( …
We hypothesized that TBA activates GPCR, resulting in activation of MMP2/9 that releases hbEGF, which activates the EGFR and/o …
miR-4443/MMP2 suppresses the migration and invasion of trophoblasts through the HB-EGF/EGFR pathway in preeclampsia.
Chen C, Gao J, Chen D, Liu J, He B, Chen Y, Zhang H, Yang X, Cheng W. Chen C, et al. Cell Cycle. 2022 Dec;21(23):2517-2532. doi: 10.1080/15384101.2022.2103897. Epub 2022 Jul 28. Cell Cycle. 2022. PMID: 35899982 Free PMC article.
Moreover, siRNA targeting MMP2 imitated the effects of overexpressed miR-4443 on HTR-8/SVneo cell invasion and migration, whereas rescue experiments showed that MMP2 reversed this inhibitory function of miR-4443. Heparin-binding EGF-like growth factor (HB-EGF), as t …
Moreover, siRNA targeting MMP2 imitated the effects of overexpressed miR-4443 on HTR-8/SVneo cell invasion and migration, whereas res …
Trophoblast survival signaling during human placentation requires HSP70 activation of MMP2-mediated HBEGF shedding.
Jain CV, Jessmon P, Barrak CT, Bolnick AD, Kilburn BA, Hertz M, Armant DR. Jain CV, et al. Cell Death Differ. 2017 Oct;24(10):1772-1783. doi: 10.1038/cdd.2017.104. Epub 2017 Jul 21. Cell Death Differ. 2017. PMID: 28731464 Free PMC article.
The HSP70 chaperone inhibitor VER 155008 blocked upregulation of both MMP2 and HBEGF at 2% O(2), and increased apoptosis. However, both HBEGF upregulation and apoptosis were rescued by exogenous MMP2. Proximity ligation assays demonstrated interactions …
The HSP70 chaperone inhibitor VER 155008 blocked upregulation of both MMP2 and HBEGF at 2% O(2), and increased apoptosis. Howe …
Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo.
Zhou ZN, Sharma VP, Beaty BT, Roh-Johnson M, Peterson EA, Van Rooijen N, Kenny PA, Wiley HS, Condeelis JS, Segall JE. Zhou ZN, et al. Oncogene. 2014 Jul 17;33(29):3784-93. doi: 10.1038/onc.2013.363. Epub 2013 Sep 9. Oncogene. 2014. PMID: 24013225 Free PMC article.
In vitro studies revealed that expression of HBEGF enhanced invadopodium formation, thus providing a mechanism for cell autonomous invasion. ...HBEGF expression also resulted in enhanced invadopodium function via upregulation of matrix metalloprotease 2 (MMP2 …
In vitro studies revealed that expression of HBEGF enhanced invadopodium formation, thus providing a mechanism for cell autonomous in …
Matrix metalloproteinases in reproductive endocrinology.
Shah BH, Catt KJ. Shah BH, et al. Trends Endocrinol Metab. 2004 Mar;15(2):47-9. doi: 10.1016/j.tem.2004.01.004. Trends Endocrinol Metab. 2004. PMID: 15080147 Review.
Recent studies by Roelle et al. showed that GnRH-induced activation of the EGF-R and extracellular signal-regulated kinases 1 and 2 (ERK1/2) in pituitary gonadotrophs occurs through ectodomain shedding of heparin binding-EGF (HB-EGF) by MMP2 and MMP9, indicating a crucial …
Recent studies by Roelle et al. showed that GnRH-induced activation of the EGF-R and extracellular signal-regulated kinases 1 and 2 (ERK1/2) …
Neurodifferentiation and Neuroprotection Potential of Mesenchymal Stromal Cell-Derived Secretome Produced in Different Dynamic Systems.
Marques CR, Fuzeta MA, Dos Santos Cunha RM, Pereira-Sousa J, Silva D, Campos J, Teixeira-Castro A, Sousa RA, Fernandes-Platzgummer A, da Silva CL, Salgado AJ. Marques CR, et al. Biomedicines. 2023 Apr 22;11(5):1240. doi: 10.3390/biomedicines11051240. Biomedicines. 2023. PMID: 37238911 Free PMC article.
Lastly, the secretomes had different profiles regarding the presence and/or specific intensity of different molecules, namely, interleukin (IL)-6, IL-4, matrix metalloproteinase-2 (MMP2), and 3 (MMP3), tumor necrosis factor-beta (TNF-beta), osteopontin, nerve growth factor …
Lastly, the secretomes had different profiles regarding the presence and/or specific intensity of different molecules, namely, interleukin ( …
Amphiregulin promotes trophoblast invasion and increases MMP9/TIMP1 ratio through ERK1/2 and Akt signal pathways.
Yu Y, Fang L, Wang S, Li Y, Guo Y, Sun YP. Yu Y, et al. Life Sci. 2019 Nov 1;236:116899. doi: 10.1016/j.lfs.2019.116899. Epub 2019 Oct 12. Life Sci. 2019. PMID: 31614145
Matrigel-transwell invasion assay was used for testing the effects of amphiregulin on cell invasiveness. MMP9 and MMP2 mRNA expression level and activity were measured using Rt-qPCR and zymographic analysis. ...
Matrigel-transwell invasion assay was used for testing the effects of amphiregulin on cell invasiveness. MMP9 and MMP2 mRNA expressio …
Abnormal Akt signalling in bladder epithelial cell explants from patients with interstitial cystitis/bladder pain syndrome can be induced by antiproliferative factor treatment of normal bladder cells.
Keay SK, Zhang CO. Keay SK, et al. BJU Int. 2016 Jul;118(1):161-72. doi: 10.1111/bju.13457. Epub 2016 Mar 29. BJU Int. 2016. PMID: 26919663
MMP2, JunB, p53, uroplakin 3 (UPK3), and beta-actin mRNAs were quantified by quantitative reverse transcriptase-polymerase chain reaction. ...IC/BPS explants also had evidence of additional downstream abnormalities compared with control cells, including lower nuclear JunB; …
MMP2, JunB, p53, uroplakin 3 (UPK3), and beta-actin mRNAs were quantified by quantitative reverse transcriptase-polymerase chain reac …
Egr2 mediates the differentiation of mouse uterine stromal cells responsiveness to HB-EGF during decidualization.
Yue L, Yu HF, Yang ZQ, Tian XC, Zheng LW, Guo B. Yue L, et al. J Exp Zool B Mol Dev Evol. 2018 Jun;330(4):215-224. doi: 10.1002/jez.b.22807. Epub 2018 May 20. J Exp Zool B Mol Dev Evol. 2018. PMID: 29781132
Knockdown of Egr2 led to a reduction in the expression of Cox-2, mPGES-1, Vegf, Trp53, and Mmp2. Further analysis found that Egr2 may serve as an intermediate to mediate the regulation of HB-EGF on Cox-2, mPGES-1, Vegf, Trp53, Mmp2, and Ccnd3. ...
Knockdown of Egr2 led to a reduction in the expression of Cox-2, mPGES-1, Vegf, Trp53, and Mmp2. Further analysis found that Egr2 may …
40 results